Key problems and methods of cost analysis based on individual cost of patients / 中国卫生政策研究

By summarizing considerations and suggested solutions of domestic and foreign researchers,the gen-eral analysis principles of cost-effectiveness analysis based on patient level data are systematically discussed,as well as the problems that need to be paid attention in the analysis,including the analysis of data set,solution of missing/censored data,consideration of whether discount should be conducted,the use of uncertainty analysis, the prepara-tion of statistical analysis plan,the analysis of intermediate follow-up point data,handling the protocol-driven costs, etc. The paper has provided reference and discussion points for the pharmaceutical economists or readers who may have interest.